Unexpected Adverse Effect of Clofarabin Plus Cytosine Arabinoside: Bronze Hyperpigmentation

Effect of uracil arabinoside on metabolism and cytotoxicity of cytosine arabinoside in L5178Y murine leukemia.

Pretreatment of L5178Y murine leukemia cells with uracil arabinoside (ara-U) enhances the cytotoxicity of cytosine arabinoside (ara-C). This effect is mediated by the cytostatic effect of ara-U, which causes a delay of cell progression through S-phase. Consequently, the specific activity of enzymes that peak during S-phase increases, and deoxycytidine kinase increases 3.6-fold over untreated co...

Clinical pharmacology of low-dose cytosine arabinoside.

Low doses of cytosine arabinoside (ara-C) have recently been administered by intravenous (IV) infusion and intermittent subcutaneous (SC) injection to patients with pre-leukemia and acute leukemia. Our studies have demonstrated that the continuous IV infusion of low-dose (20 mg/m2/d) ara-C produces hematologic improvement in patients with preleukemic syndromes. The present work has monitored pl...

The clinical pharmacology of cytosine arabinoside.

Experimental retinal dysplasia due to cytosine arabinoside.

Retinal dysplasia was produced in newborn rats treated postnatally with the antimitotic substance, cytosine arabinoside (ara-C). In rats examined from 6 to 60 days, there were numerous retinal rosettes surrounded by photoreceptor cells and bipolar cells containing photoreceptor cell processes, displaced nuclei, and cellular debris. Abnormal development and alignment of photoreceptor cell proces...

Hybrid Model of Erythropoiesis and Leukemia Treatment with Cytosine Arabinoside

A hybrid model of cell population dynamics, where cells are discrete elements whose dynamics depend on continuous intracellular and extracellular processes, is developed to simulate the evolution of immature red blood cells in the bone marrow. Cell differentiation, self-renewal or apoptosis are determined by an intracellular network, based on two proteins, Erk and Fas, and described by ordinary...